Gastro Stasis

Hi,

This is my first time in this group, I've had migraines from the age of 13 monthly which became chronic about 6 yrs ago , I'm 47 now and thoroughly fed up but I'm still looking for answer's, I'm on prevent as well as rescue and lots of other pills to make me rattle. I became involved with a Chronic Migraine Awareness a while back mainly the research after realising that gastro stasis could be having more than a temporary effect on my gut, which stops everytime a have an attack. I've read that stasis can have a real effect on the over & malabsorption of drug's with migraneur's and in my case causing intermittant toxicity.

Below is a link to one of the articles I've seen and I'm after any more info I can find on stasis, trigger's, aura types etc - I had to tell my doc I had aura after 30 years - ollfactory hallucination's - my doc had never heard of it.

Gastric Stasis in Migraine: More Than Just a Paroxysmal Abnormality During a Migraine Attack
This is just a little bit of the article :-)

Conclusions.—Contrary to previous belief, this study has demonstrated that migraineurs suffer from gastric stasis both during and outside an acute migraine attack. This may suggest that migraineurs may have an abnormal autonomic function compared to nonmigrainous controls. The potential role of this in pathophysiology of migraine is discussed and avenues for further investigations are explored.

*Dear Admin, would it be possible for you to contact me as I'd like your permission to put either a link to or the current list of migraine symptom's I've collated in the hope that you / your member's can add to it and use it - Thanks.
If you cannot access my email address I can be found at the CMA UK [ Facebook ]

I've never heard of gastro stasis though I'm interested to read about it. Usually I can just copy a website address and paste it here. That works fine.

Hi,

I can't put a link on till I've been here a week [ I think ]
I come from a long line of miggy's and each one has had similar problems, so I sat my rear in front of pc and stuck in the only word I could remember from school 'peristalsis' and followed a word trail. I'm upto my ears in it now,
migraine not good for thinking lol, as soon as I can I'll pop them on here.

I'm in the UK and the amount of info our Gp's have is very little, took me 30 yrs to get into a migraine clinic !
I jumped online and found out bout the cycle / triggers / aura's etc etc. Then the gut stopping info jumped off screen, I'' see if I can find the links and type info in here.

I've been on a couple of groups [ prob more than a couple ] I keep asking the same questions about stasis , could we be overdosing/underdosing like a rollercoaser on meds that are absorbed in small intestine not stomach ? pharma co, specialist in migraine / gastro / neuro / liver etc etc nobody will put their money where their mouth is ??

Nice to have another member-WELCOME I would be very interested in this. I get this about every 3 months with prolonged migraine. Usually leads to severe episodes of vomiting.

This is what sends me to ER. I have come to believe that some meds I was using seem to contribute, like Lidoderm patch and Midrin. Although not sure what comes first the gastro stasis or just too many combos of meds. It seems the less I combine the better off I am.Please post the links when you can.
Hugs,
Cindy

Not just migraine that can screw up other med's we've got drug interactions that can inhibit or 'condense'
My doc recently prescribed Zantac for abdominal pain - I slept and slept when I wasn't sleeping I wasn't safe.

I googled my other meds and found that zantac [ proton pump inhibitor ] actually increased the serum levels of my other med's to toxic level :-| ?!

unbelievable another failed druggling attempt by doc. To make it worse the abdominal pain could be due to my other meeds and nothing to do with acid :-o

Try googling this or see if you can hit the webpage

Migraine attacks commonly activate the sympathetic nervous system in the body.
Sympathetic activity also delays emptying of the stomach into the small intestine and thereby
prevents oral medications from entering the intestine and being absorbed.

Medical Author: Dennis Lee, M.D.
Medical Editors: Harley I. Kornbum, M.D., Ph.D., Jay W. Marks, M.D. 7/29/02
© 1996-2003 MedicineNet, Inc. All rights reserved

skylinefamilypractice.net/PtED/MigraineHA.htm

I'm having spikes today so apologies if my typo is a little off :-) I can't say I'll be here regularly meds & heads make me a dull girl lol but will try to get info on here if thats ok with admin :-)

It may not be the med's as a whole, I've found that the capsules can have an effect all depends on the drugs and how many drug's we are druggling at once I'm on 14 and hoping it will be down to under 5 by march.

I found earlier this year I had macrocytic anaemia brought on by long term medication which had caused a folate deficiency and the side effect of no folic = headache = migraine triggered for about 6 weeks total.

After that I had friends doing research, as well as the CMA guy's and me when I could , turned out i was having all sorts of side effects and vit deficiensies that docs didn't spot for about 4 - 5 yrs.

Madness is I have to be mig free for a couple of days before i can read and follow it.

Welcome to the forum, Nevynxx


I will look into complexities of adding links by the "newbies", but I don't think you need any special privileges to post any.
Can you try again to simply 'copy and paste' one - just make sure you got the URL correct.

Also, may I solemnly invite you to our Miscellaneous side where coincidentally we recently have opened out Introduction thread -
you came in just right on time for this one !! come on, over, then, new Fabulous friend!


Risa

I tried and it still wont let me post till I've been here a minimum of 7 day's, had a look for misc - I think i need a good nights sleep, spent all day trying to sort out a problem on another group - absolutely bushed xx

Hi All,

Welcome to our little corner of the web.

I'm sorry you are having such a rough time. I know migraines can cause me to lose my speech, my ability to read, and it can certainly mess with the GI symptoms. I don't know if the migraine is causing the problem, but since it can cause people to vomit until they become dehydrated, I am sure it can stop the system as well. Some of the medications can also cause bad constipation or other GI symptoms.

I'm surprised that your GP hadn't heard of aura before. Certainly, he must have seen it or heard of it before! But, many doctors and many neuros I have met are not as educated as they should be on the subject of migraine. So it is possible. Is there anyway you could get in with a GI specialist? or get that checked out?

As to the link stuff, you can usually press the link button and copy the information.

Pain free days,
sconesail

I have checked my admin tools, and probably (most definitely!) I am A tool lolol
but nowhere I could find anything about one week wait re: posting links.
Where did you read about that, please? I am curious...

Sorry I am of no help...

Risa

I can write reply including links, but when I go to post a message comes up 'you cannot post links until you have been a member for 7 days', I can reply minus the links.

Sorry it took a while to reply, I'm having a rough trot with the increase in meds and I'm just coming out of a 4 week mig after headbutting a wall :-o but the added stress of a british migraine site on facebook, suggesting I'm not a nice person and not being very nice about my friends in the states and the migraine charity they set up - she's good it's a closed group and I can't defend myself without making a bad situation worse.

So if I'm hit and miss I'll apologise, I have to keep the facebook group upto date as well as an upcoming tribunal here in the uk and watch my back x

you could always put it in as text, not a link. For example amazon dot com

There is a text one further up.

Sorry bout this having a bad time and the woman on facebook is making me out to be something I'm not, can't defend myself and migraine / med's knocking me sideways. just very tired x

Don't let it get to you. None of us come to these things to get more stress and headaches, which is a good reminder for that Facebook site. Sometimes people just need to be reminded to chill.

Thanks, but this old girl just won't let up, she's put my fullname on her closed group, only found out because another member was concerned about this obsession, and she left because she wasn't keen on how it was run, I've no idea if she has removed her post's with my name or not and then I got a friend request from a stranger, I've got to point where I'm blocking people just in case. I was in her group and she made what can only be classed as a disablist remark on a thread I'd started, I pulled her up on it - she wouldn't budge so I removed the thread and all hell broke loose, a woman shouting via message, then she really got started trying to drive a wedge between a good friend and then the other's started checking me out ! Now she's threatening to have me thrown off - she has about 4 groups on f/b as well as god knows how many in forum's.

Migraines and other health problems are bad enough - but this one ! never come across anything like it and I thought she was a lonely old lady on verge of a breakdown, more fool me.

Apart from that, If anyone is taking Depakote they may like to check on long term side effects and the effect it has on the central nervous system, I've been looking at similar with phenytoin - not nice and need to be on lookout for side effects x

http://www.ncbi.nlm.nih.gov/pubmed/16412152

http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2006.00311.x/full


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886367/


http://headaches.about.com/od/migrainedisease/a/gastric_stasis.htm

http://www.mappharma.com/file.cfm/124/docs/GS_AAN2_Web.pdf

fingers crossed this will post

They all posted beautifully
I am perusing them right now, thanks!

Risa

An interesting set of articles. Thanks for hanging in there long enough to be able to post them.

I rarely (thank God) get nausea during my migraines. It has happened a few times and its no fun at all. I generally have very little appetite during a migraine though and eat very light.

But I do have GERD (which started before the migraines) and earlier this year I had my gallbladder removed after a year of attacks. They finally found my gallbladder was diseased after it was very slow in an emptying test.
So, yes it does seem I have symptoms of this slowed GI syndrome. Very strange. I've never heard of it before.

Thanks for the info!

It's very rare I get nausea , in 30 yrs I think I've thrown up a handful of times, but family history - when a mig start's we don't go to the loo until mig has finished, I thought this may have something to do with current health probs as experiencing toxicity with normal blood levels. I started on peristalsis [ only word I could remember from biology ] and the majority of what I was thinking , they'd been looking at for some time. I've tried gastro / neuro / the people who wrote some of the papers to see if alkaline drugs which are absorbed through small intestine could fluctuate and cause toxicity with those drugs ?? Only one to come back to me was the migraine trust . . . .

Reply:
With regards to your question about gastric stasis during migraine and whether this can affect the Phenytoin which you have taken, I put your query to The Migraine Trust’s medical Trustees, who are consultant neurologists and headache specialists, and their reply is that they think it very unlikely that the degree of gastric stasis during a migraine attack would be sufficient to affect Phenytoin absorption to the extent that it would have an adverse pharmokinetic effect i.e. affect plasma levels.

The point about the fact that you say that you have experienced symptoms of possible drug toxicity in the presence of normal non-toxic phenytoin levels, The Migraine Trust’s medical Trustees said that this is not uncommon with several drugs where levels can be measured. An individual’s tolerability of specific drugs is very variable and symptoms of toxicity can occur even in the context of normal plasma levels as the drug level does not always accurately reflect the concentration of drug at the relevant CNS [central nervous system] receptor level.

Our medical Trustees also said that it is not really possible to be completely certain in this scenario particularly when dealing with a drug like phenytoin the pharmacokinetics of which are so unpredictable.

This link gives info on food / drug interactions
http://www.itmonline.org/arts/herbdrug.htm

Sorry, late to the party. I think we set up that no posting links thing until seven posts to prevent spammers. It is working. Most spammers try it and then leave. I'm glad you are able to post now. . Sorry if it caused you some trouble.

Sounds like you have been having a rough time on migraine pages. This one is nice and chill and we simply use common courtesy and it seems to work. Glad to have you find us.

Very sensible, seen too many spammers :-) No trouble. Main concern is getting the info to pass on to other's like us - I'm 5th generation had no idea of the cycle or that I actually had aura [ thought it was just floaters ] mine ollfactory hallucinations after I'd dumped what I thought was smell stuff inc a lot of furniture lol. My doc's not clued up and one even said I was exaggerating pain of hemi. Not just gastro either that affects drugs - putting a link to contraceptive that messes with lamictal don't worry - under another topic lol.

It was only one facebook group, 1 woman. The CMA bunch have been brilliant - hence the links :-)